Resveratrol delays the progression of diabetic nephropathy through multiple pathways: A dose-response meta-analysis based on animal models.

ABSTRACT:

Objective

Accumulating experimental evidence has shown that resveratrol supplementation is effective for treating diabetic nephropathy (DN) in animal models. In this systematic review and meta-analysis, we assessed the effects and multiple mechanisms of resveratrol in animal models of DN.

Methods

Before September 2023, preclinical literature was systematically searched and screened across PubMed, Web of Science, EMBASE, and the Cochrane Library. Forty-two studies were included, and the risk of bias tool from SYRCLE was used to assess the methodological quality. Pooled overall effect sizes of the results were generated by STATA 16.0.

Results

The overall results provide preliminary evidence that the consumption of resveratrol can significantly reduce the mesangial index

SUBMITTER: Liu X 

PROVIDER: S-EPMC11391385 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature