Case report: Personalizing the use of trazodone in real-world patients: a study of three cases of depression with comorbidities.

ABSTRACT: Depressive disorders are leading contributors to the global mental health-related burden, and they represent a challenge for real-world clinicians, due to the low rates of remission despite the high availability of treatments. Often, depression shows in the context of multiple chronic comorbidities, thus requiring precise and accurate management of pharmacological treatments to avoid interactions and side effects. These criticalities call for the need for new strategies of treatment, which may include new insights into the pharmacological properties of currently available antidepressant drugs, to enhance their efficacy in the different contexts in which depression may arise. Trazodone is the prototype serotonin antagonist/reuptake inhibitor antidepressant (SARI). Due to the malleability gr

SUBMITTER: Rosso G 

PROVIDER: S-EPMC11391422 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature