Environmental Influence on Bacterial Lipid Composition: Insights from Pathogenic and Probiotic Strains.

ABSTRACT: The lipid composition of bacterial membranes is pivotal in regulating bacterial physiology, pathogenicity, and interactions with hosts. This study presents a comprehensive analysis of bacterial membrane lipid profiles across diverse Gram-positive and Gram-negative species. Utilizing matrix-assisted laser desorption/ionization (MALDI) in conjunction with advanced chemometric tools, we investigate the influence of environmental factors, isolation sources, and host metabolism on bacterial lipid profiles. Our findings unveil significant variations in lipid composition attributed to factors such as carbon/energy availability and exposure to chemicals, including antibiotics. Moreover, we identify distinct lipidomic signatures associated with pathogenic and probiotic bacterial strains, shedding l

SUBMITTER: Walczak-Skierska J 

PROVIDER: S-EPMC11391446 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature