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Green One-Pot Synthesis of Thiazole Scaffolds Catalyzed by Reusable NiFe₂O₄ Nanoparticles: In Silico Binding Affinity and In Vitro Anticancer Activity Studies.

ABSTRACT: A facile, green, one-pot multicomponent synthesis strategy was employed to fabricate novel thiazole scaffolds incorporating phthalazine, pyridazine, and pyrido-pyridazine derivatives (4a-4o). This synthetic route entailed the reaction of an α-halo carbonyl compound (1) with thiosemicarbazide (2) and various anhydrides (3a-3o), utilizing NiFe₂O₄ nanoparticles as a reusable catalyst in an ethanol:water (1:1) solvent system. The cytotoxicity of the synthesized compounds was meticulously assessed against three cancer cell lines, A375, HeLa, and MCF-7, employing IC₅₀ values (μM) as the benchmark, and compared to the reference drug erlotinib. Compound 4n displayed remarkable efficacy against A375 (0.87 ± 0.31 μM),

SUBMITTER: Gudala S

PROVIDER: S-EPMC11391536 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature

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Green One-Pot Synthesis of Thiazole Scaffolds Catalyzed by Reusable NiFe₂O₄ Nanoparticles: In Silico Binding Affinity and In Vitro Anticancer Activity Studies.

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Green One-Pot Synthesis of Thiazole Scaffolds Catalyzed by Reusable NiFe2O4 Nanoparticles: In Silico Binding Affinity and In Vitro Anticancer Activity Studies.

OmicsDI is part of the ELIXIR infrastructure

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Green One-Pot Synthesis of Thiazole Scaffolds Catalyzed by Reusable NiFe₂O₄ Nanoparticles: In Silico Binding Affinity and In Vitro Anticancer Activity Studies.