Ageing results in an exacerbated inflammatory response to LPS by resident lung cells.

ABSTRACT:

Background

Ageing is associated with an increased risk of lung infection and chronic inflammatory lung disease. Innate immune responses are the first line of defence in the respiratory tract, however, age-related changes to innate immunity in the lung are not fully described. Both resident haematopoietic cells, such as alveolar macrophages, and non-haematopoeitic cells, such as epithelial and endothelial cells can contribute to inflammatory and immune responses in the lung. In this study we aimed to determine the impact of ageing on early innate responses of resident cells in the lung.

Results

Aged and young mice were inoculated intranasally with lipopolysaccharide (LPS). After 4 h, aged mice recruited higher numbers of neutrophils to the airways and lung. This exacerbated i

SUBMITTER: Diaz-Nicieza C 

PROVIDER: S-EPMC11391591 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature