Mendelian randomization analysis reveals causal effects of blood lipidome on gestational diabetes mellitus.

ABSTRACT:

Background

Observational studies have revealed associations between maternal lipid metabolites and gestational diabetes mellitus (GDM). However, whether these associations are causal remain uncertain.

Objective

To evaluate the causal relationship between lipid metabolites and GDM.

Methods

A two-sample Mendelian randomization (MR) analysis was performed based on summary statistics. Sensitivity analyses, validation analyses and reverse MR analyses were conducted to assess the robustness of the MR results. Additionally, a phenome-wide MR (Phe-MR) analysis was performed to evaluate potential side effects of the targeted lipid metabolites.

Results

A total of 295 lipid metabolites were included in this study, 29 of them had three or more instrumental variables (IVs)

SUBMITTER: Dong Y 

PROVIDER: S-EPMC11391602 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature