Discovering common pathogenetic processes between periodontitis and Alzheimer's disease by bioinformatics and system biology approach.

ABSTRACT:

Background

There is increasing evidence that inflammation plays a key role in the pathophysiology of periodontitis (PT) and Alzheimer's disease (AD), but the roles of inflammation in linking PT and AD are not clear. Our aim is to analyze the potential molecular mechanisms between these two diseases using bioinformatics and systems biology approaches.

Methods

To elucidate the link between PT and AD, we selected shared genes (SGs) with gene-disease-association scores of ≥ 0.1 from the Disease Gene Network (DisGeNET) database, followed by extracting the hub genes. Based on these genes, we constructed gene ontology (GO) enrichment analysis, pathway enrichment analysis, protein-protein interaction (PPI) networks, transcription factors (TFs)-gene networks, microRNAs (miRNAs)-gene

SUBMITTER: Ge F 

PROVIDER: S-EPMC11391628 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature