Quantification of the interaction forces between dengue virus and dopamine type-2 receptor using optical tweezers.

ABSTRACT:

Background

Dengue virus (DENV) causes the most significant mosquito-borne viral disease with a wide spectrum of clinical manifestation, including neurological symptoms associated with lethal dengue diseases. Dopamine receptors are expressed in central nervous system, and dopamine antagonists have been reported to exhibit antiviral activity against DENV infection in vivo and in vitro. Although identification of host-cell receptor is critical to understand dengue neuropathogenesis and neurotropism, the involvement of dopamine receptors in DENV infection remains unclear.

Results

We exploited the sensitivity and precision of force spectroscopy to address whether dopamine type-2 receptors (D2R) directly interact with DENV particles at the first step of infection. Using optical tw

SUBMITTER: Arifin JC 

PROVIDER: S-EPMC11391641 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature