Prognostic impact of nectin-like molecule-5 (CD155) expression in non-small cell lung cancer.

ABSTRACT:

Background

CD155 is a transmembrane protein that inhibits antitumor immune response and represents a predictor of worse prognosis in non-small-cell lung cancer (NSCLC). However, it remains unexplored its association with clinical characteristics and genomic status of Latin American patients. This study characterizes the CD155 expression and its clinical implications in this population.

Methods

Tissue biopsies from 86 patients with locally-advanced or metastatic NSCLC were assessed for CD155 protein expression, ALK rearrangements and EGFR mutations. Cutoff values for high CD155 expression (CD155^high) were determined from receiver operating characteristic (ROC) curves according to 2-year survival. It was evaluated its association with clinicopathological features, m

SUBMITTER: Xitlally PN 

PROVIDER: S-EPMC11391680 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature