Effect of estradiol supplementation on luteal support following a significant reduction in serum estradiol levels after hCG triggering: a prospective randomized controlled trial.

ABSTRACT:

Objective

This study aimed to evaluate the impact of adding 4 mg estradiol valerate to progesterone for luteal support on pregnancy rates in IVF cycles following a long protocol with reduced luteal serum estradiol levels post-hCG triggering.

Design, setting, and participants

The prospective randomized controlled trial was conducted at a public tertiary hospital reproductive center with 241 patients who experienced a significant decrease in serum estrogen levels post-oocyte retrieval.

Interventions

Participants received either a daily 4 mg dose of estradiol valerate in addition to standard progesterone or standard progesterone alone for luteal support.

Results

The ongoing pregnancy rate did not show a significant difference between the E2 group and the control g

SUBMITTER: Li N 

PROVIDER: S-EPMC11391712 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature