Cepharanthine attenuates pulmonary fibrosis via modulating macrophage M2 polarization.

ABSTRACT:

Background

Idiopathic pulmonary fibrosis (IPF) is a group of chronic interstitial pulmonary diseases characterized by myofibroblast proliferation and extracellular matrix (ECM) deposition. However, current treatments are not satisfactory. Therefore, more effective therapies need to be explored. Cepharanthine (CEP) is a naturally occurring alkaloid that has recently been reported to have multiple pharmacological effects, particularly in chronic inflammation.

Methods

For in vivo experiments, first, a pulmonary fibrosis murine model was generated via tracheal injection of bleomycin (BLM). Second, the clinical manifestations and histopathological changes of the mice were used to verify that treatment with CEP might significantly reduce BLM-induced fibrosis. Furthermore, flow cyt

SUBMITTER: Bao J 

PROVIDER: S-EPMC11391720 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature