Large-scale analysis reveals spatiotemporal circadian patterns of cilia transcriptomes in the primate brain.

ABSTRACT: Cilia are dynamic subcellular systems, with core structural and functional components operating in a highly coordinated manner. Since many environmental stimuli sensed by cilia are circadian in nature, it is reasonable to speculate that genes encoding cilia structural and functional components follow rhythmic circadian patterns of expression. Using computational methods and the largest spatiotemporal gene expression atlas of primates, we identified and analyzed the circadian rhythmic expression of cilia genes across 22 primate brain areas. We found that around 73% of cilia transcripts exhibited circadian rhythmicity across at least one of 22 brain regions. In 12 brain regions, cilia transcriptomes were significantly enriched with circadian oscillating transcripts, as compared to the rest o

SUBMITTER: Baldi P 

PROVIDER: S-EPMC11391745 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature