Mitochondrial sequence variants: testing imputation accuracy and their association with dairy cattle milk traits.

ABSTRACT:

Background

Mitochondrial genomes differ from the nuclear genome and in humans it is known that mitochondrial variants contribute to genetic disorders. Prior to genomics, some livestock studies assessed the role of the mitochondrial genome but these were limited and inconclusive. Modern genome sequencing provides an opportunity to re-evaluate the potential impact of mitochondrial variation on livestock traits. This study first evaluated the empirical accuracy of mitochondrial sequence imputation and then used real and imputed mitochondrial sequence genotypes to study the role of mitochondrial variants on milk production traits of dairy cattle.

Results

The empirical accuracy of imputation from Single Nucleotide Polymorphism (SNP) panels to mitochondrial sequence genotypes was

SUBMITTER: Dorji J 

PROVIDER: S-EPMC11391750 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature