Polymorphisms of CD247 gene is associated with dilated cardiomyopathy in Chinese Han population.

ABSTRACT:

Background

Dilated cardiomyopathy (DCM) is a major cause of heart failure and heart transplantation. Recently, some studies have reported that the autoimmune response in myocardial cells might be related to the pathogenesis of DCM. The CD247 gene has been previously found to be involved in autoimmune disease. Therefore, our study aimed to clarify the hypothesis that there is a certain linkage between polymorphisms of the CD247 gene and the triggering of DCM risk.

Methods

In the present study, two single nucleotide polymorphisms (SNPs) of the CD247 gene, rs12141731 and rs858543, were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 355 DCM patients and 404 age- and sex-matched controls.

Results

Pearson's chi-squared test for

SUBMITTER: Li C 

PROVIDER: S-EPMC11391773 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature