RAS mutation associated with short surgically controllable period in colorectal liver metastases: a retrospective study.

ABSTRACT:

Background

The prognostic implications of the RAS status in colorectal cancer liver metastasis (CRLM) remain unclear. This study investigated the prognostic significance of RAS status after curative hepatectomy, focusing on surgical controllability.

Methods

This retrospective study included liver-only CRLM patients who underwent the first hepatectomy between 2015 and 2022 at the National Cancer Center Hospital. Recurrence-free survival (RFS), surgically controllable period (SCP), and overall survival (OS) were compared between RAS wild-type (RAS-wt) and mutant (RAS-mt) patients. Multivariate analyses were conducted to identify independent prognostic factors for each outcome and independent risk factors for less than 1 year SCP.

Results

A total of 150 patients were eva

SUBMITTER: Ito S 

PROVIDER: S-EPMC11391794 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature