Creatinine-to-cystatin C ratio and frailty in older adults: a longitudinal cohort study.

ABSTRACT:

Background

Creatinine-to-cystatin C ratio (CCR) has been associated with multiple adverse outcomes. However, little is known about its relationship with frailty. We aimed to explore the association between CCR and frailty among older adults.

Methods

A total of 2599 participants aged ≥ 60 years (mean age 67.9 ± 6.0 years, 50.4% males) were included from the China Health and Retirement Longitudinal Study (2011-2015). Baseline CCR was calculated as plasma creatinine (mg/dL) / cystatin C (mg/L) × 10 and was grouped by quartiles. Frailty was evaluated by the validated physical frailty phenotype (PFP) scale and was defined as PFP score ≥ 3. The generalized estimating equations model was used to explore the relationship between CCR and frailty.

Results

The frailty risk decre

SUBMITTER: Song Q 

PROVIDER: S-EPMC11391795 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature