Genetically predicted effects of 10 sleep phenotypes on revision of knee arthroplasty: a mendelian randomization study.

ABSTRACT:

Background

Accumulating evidence has suggested that sleep disturbances and disorders are common in patients who undergo knee arthroplasty. Revision surgery represents one of the most catastrophic outcomes of knee arthroplasty. However, it remains unclear whether sleep traits are the causes or consequences of knee arthroplasty revision. This study aimed to genetically examine the relationships between sleep traits and knee arthroplasty revision.

Methods

To determine the causal relationship between sleep traits and knee arthroplasty revision, we employed two-sample Mendelian randomization (MR) using summary statistics from the largest publicly available genome-wide association studies (GWASs). The MR design uses genetic variants as instrumental variables to help separate causa

SUBMITTER: Bi Z 

PROVIDER: S-EPMC11391806 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature