Association between copper intake and essential hypertension: dual evidence from Mendelian randomization analysis and the NHANES database.

ABSTRACT:

Background

Although previous studies have identified an association between trace elements and essential hypertension, the specific trace elements involved and the mechanisms of their association remain unclear. This study aimed to elucidate the relationship between various human trace elements and essential hypertension, thereby addressing existing gaps in the research.

Methods

This study employed two-sample, multivariate, and inverse Mendelian randomization (MR) analyses to investigate the causal relationship between 15 human trace elements as exposure factors and essential hypertension as the outcome. The analysis revealed a statistically significant association between copper intake and essential hypertension. Further validation was conducted using logistic regression mo

SUBMITTER: Miao Q 

PROVIDER: S-EPMC11391934 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature