Organ chips with integrated multifunctional sensors enable continuous metabolic monitoring at controlled oxygen levels.

ABSTRACT: Despite remarkable advances in Organ-on-a-chip (Organ Chip) microfluidic culture technology, recreating tissue-relevant physiological conditions, such as the region-specific oxygen concentrations, remains a formidable technical challenge, and analysis of tissue functions is commonly carried out using one analytical technique at a time. Here, we describe two-channel Organ Chip microfluidic devices fabricated from polydimethylsiloxane and gas impermeable polycarbonate materials that are integrated with multiple sensors, mounted on a printed circuit board and operated using a commercially available Organ Chip culture instrument. The novelty of this system is that it enables the recreation of physiologically relevant tissue-tissue interfaces and oxygen tension as well as non-invasive continuou

SUBMITTER: Izadifar Z 

PROVIDER: S-EPMC11391946 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature