Dexmedetomidine use during orthotopic liver transplantation surgery on early allograft dysfunction: a randomized controlled trial.

ABSTRACT:

Background

Previous studies have shown a protective effect of dexmedetomidine use in kidney transplantation. In contrast, it is not known whether intraoperative administration of dexmedetomidine can reduce early allograft dysfunction (EAD) incidence following liver transplantation.

Objective

To investigate the effect of dexmedetomidine use during surgery on EAD following orthotopic liver transplantation (OLT).

Study design

This is a single-center, double-blinded, placebo-controlled randomized clinical trial. Three hundred thirty adult patients undergoing OLT were enrolled from 14th January 2019 to 22nd May 2022. Patients received dexmedetomidine or normal saline during surgery. One year follow-ups were recorded.

Methods

Patients were randomized to two groups re

SUBMITTER: Yang L 

PROVIDER: S-EPMC11392095 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature