Assessing the fragility index of randomized controlled trials supporting perioperative care guidelines: A methodological survey protocol.

ABSTRACT:

Introduction

The Fragility Index (FI) and the FI family are statistical tools that measure the robustness of randomized controlled trials (RCT) by examining how many patients would need a different outcome to change the statistical significance of the main results of a trial. These tools have recently gained popularity in assessing the robustness or fragility of clinical trials in many clinical areas and analyzing the strength of the trial outcomes underpinning guideline recommendations. However, it has not been applied to perioperative care Clinical Practice Guidelines (CPG).

Objectives

This study aims to survey clinical practice guidelines in anesthesiology to determine the Fragility Index of RCTs supporting the recommendations, and to explore trial characteristics associa

SUBMITTER: Otalora-Esteban M 

PROVIDER: S-EPMC11392262 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature