Radiologic Classification of Hippocampal Sclerosis in Epilepsy.

ABSTRACT: Temporal lobe epilepsy is a common form of epilepsy that is often associated with hippocampal sclerosis (HS). Although HS is commonly considered a binary assessment in radiologic evaluation, it is known that histopathologic changes occur in distinct clusters. Some subtypes of HS only affect certain subfields, resulting in minimal changes to the overall volume of the hippocampus. This is likely a major reason why whole hippocampal volumetrics have underperformed versus expert readers in the diagnosis of HS. With recent advancements in MRI technology, it is now possible to characterize the substructure of the hippocampus more accurately. However, this is not consistently addressed in radiographic evaluations. The histologic subtype of HS is critical for prognosis and treatment decision-makin

SUBMITTER: Middlebrooks EH 

PROVIDER: S-EPMC11392372 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature