Development of Myelin Growth Charts of the White Matter Using T1 Relaxometry.

ABSTRACT:

Background and purpose

Myelin maturation occurs in late fetal life to early adulthood, with the most rapid changes observed in the first few years of infancy. To quantify the degree of myelination, a specific MR imaging sequence is required to measure the changes in tissue proton relaxivity (R1). R1 positively correlates with the degree of myelination maturation at a given age. Similar to head circumference charts, these data can be used to develop normal growth charts for specific white matter tracts to detect pathologies involving abnormal myelination.

Materials and methods

This is a cross-sectional study using normal clinical pediatric brain MR images with the MP2RAGE sequence to generate T1 maps. The T1 maps were segmented to 75 brain regions from a brain atlas (white ma

SUBMITTER: Ho CY 

PROVIDER: S-EPMC11392380 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature