A GCaMP reporter mouse with chondrocyte specific expression of a green fluorescent calcium indicator.

ABSTRACT: One of the major processes occurring during the healing of a fractured long bone is chondrogenesis, leading to the formation of the soft callus, which subsequently undergoes endochondral ossification and ultimately bridges the fracture site. Thus, understanding the molecular mechanisms of chondrogenesis can enhance our knowledge of the fracture repair process. One such molecular process is calciun (Ca⁺⁺) signaling, which is known to play a critical role in the development and regeneration of multiple tissues, including bone, in response to external stimuli. Despite the existence of various mouse models for studying Ca⁺⁺ signaling, none of them were designed to specifically examine the skeletal system or the various musculoskeletal cell types. As such, we generated a g

SUBMITTER: Tsadaris SA 

PROVIDER: S-EPMC11392458 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature