Persistent endocrine-disrupting chemicals and incident uterine leiomyomata: A mixtures analysis.

ABSTRACT:

Background

Uterine leiomyomata (UL; fibroids) are hormone-dependent neoplasms that can cause significant gynecologic morbidity. Studies have documented associations between concentrations of persistent endocrine-disrupting chemicals (EDCs) and UL incidence; however, few have assessed the effects of EDC mixtures on UL.

Methods

In the Study of Environment, Lifestyle, and Fibroids, a prospective cohort study, participants attended study visits at baseline and approximately every 20 months for up to 10 years; at each visit, they completed questionnaires, provided blood samples, and underwent standardized ultrasound examinations. In baseline plasma samples (n = 1155), we quantified concentrations of polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and org

SUBMITTER: Wesselink AK 

PROVIDER: S-EPMC11392607 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature