Microparticle Mediated Delivery of Apelin Improves Heart Function in Post Myocardial Infarction Mice.

ABSTRACT:

Background

Apelin is an endogenous prepropeptide that regulates cardiac homeostasis and various physiological processes. Intravenous injection has been shown to improve cardiac contractility in patients with heart failure. However, its short half-life prevents studying its impact on left ventricular remodeling in the long term. Here, we aim to study whether microparticle-mediated slow release of apelin improves heart function and left ventricular remodeling in mice with myocardial infarction (MI).

Methods

A cardiac patch was fabricated by embedding apelin-containing microparticles in a fibrin gel scaffold. MI was induced via permanent ligation of the left anterior descending coronary artery in adult C57BL/6J mice followed by epicardial patch placement immediately after (acut

SUBMITTER: Tang L 

PROVIDER: S-EPMC11392624 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature