A study on the causal relationship between the gut microbiome and herpes zoster using Mendelian randomization.

ABSTRACT:

Introduction

The relationship between herpes zoster recurrence and the gut microbiome was not studied. We analyzed data on the gut microbiome and herpes zoster from the Large-Scale Genome-Wide Association Study (GWAS) database using bidirectional Mendelian randomization. For the first time, we identified a potentially bidirectional causal relationship between the gut microbiome and herpes zoster (HZ). These findings are groundbreaking and hold promise for new directions in the treatment of HZ, a global disease.

Background and aims

HZ had a high global incidence, characterized by shingled blisters, blood blisters, and neuropathic pain, and could develop in various parts of the body, including the ear and throat. It was believed its onset was closely related to old age and inf

SUBMITTER: Meng Z 

PROVIDER: S-EPMC11392744 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature