Right-to-left shunt-associated brain functional changes in migraine: evidences from a resting-state FMRI study.

ABSTRACT:

Background

Migraine, a neurological condition perpetually under investigation, remains shrouded in mystery regarding its underlying causes. While a potential link to Right-to-Left Shunt (RLS) has been postulated, the exact nature of this association remains elusive, necessitating further exploration.

Methods

The amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo) and functional connectivity (FC) were employed to investigate functional segregation and functional integration across distinct brain regions. Graph theory-based network analysis was utilized to assess functional networks in migraine patients with RLS. Pearson correlation analysis further explored the relationship between RLS severity and various functional metrics.

SUBMITTER: Cao W 

PROVIDER: S-EPMC11392749 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature