A Mendelian randomization study of genetic liability to cutaneous melanoma and sunburns.

ABSTRACT:

Background

Some studies have reported that sunburns and cutaneous melanoma (CM) risk is increasing, but a clear causal link has yet to be established.

Methods

This current study conducted a two-sample Mendelian randomization (MR) approach to clarify the association and causality between sunburn history and CM using large-scale genome-wide association study data.

Results

The inverse-variance weighted method result showed that sunburn might be associated with the risk of CM increasing (p = 2.21 × 10^-23, OR = 1.034, 95% CI= 1.027-1.041), causally. The MR-Egger regression, weighted median method, simple mode method, and weighted mode method results showed similar results.

Conclusion

This study offers evidence of sunburn history and increased risk of CM,

SUBMITTER: Lu F 

PROVIDER: S-EPMC11392754 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature