Association between air pollution and cerebrospinal fluid alpha-synuclein in urban elders: the CABLE study.

ABSTRACT:

Introduction

Increasing evidence suggests that air pollution has a significant impact on the development of synucleinopathies, but the potential neurobiological mechanisms are unknown. We aimed to explore the associations of air pollution (including ozone [O₃], nitrogen dioxide [NO₂], and particulate matter [PM_2.5]) with CSF α-syn levels in urban older adults.

Methods

We included 933 urban participants from the Chinese Alzheimer's Biomarker and LifestylE study. The 5-year average levels of air pollution exposure were estimated in the areas of residence. Multivariate linear regression was conducted to detect the correlation of air pollution with CSF α-syn levels. Subgroup analyses by age, gender, season, and history of coronary heart disease (

SUBMITTER: Wang AY 

PROVIDER: S-EPMC11392785 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature