Unveiling the cellular landscape: insights from single-cell RNA sequencing in multiple myeloma.

ABSTRACT:

Objective

The aim of this research was to gain a thorough understanding of the processes involved in cell communication and discover potential indicators for treating multiple myeloma (MM) through the use of single-cell RNA sequencing (scRNA-seq). And explored the expression of multiple myeloma-related subgroups on metal ion-related pathways to explore the relationship between MM and metal ions.

Methods

We performed a fair examination using single-cell RNA sequencing on 32 bone marrow specimens collected from 22 individuals at different points of MM advancement and 9 individuals without any health issues. To analyze the scRNA-seq data, we employed advanced computational algorithms, including Slingshot, Monocle2, and other methodologies. Specifically, Slingshot and Monocle2 e

SUBMITTER: Li X 

PROVIDER: S-EPMC11392786 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature