Causal role of gut microbiota, serum metabolites, immunophenotypes in myocarditis: a mendelian randomization study.

ABSTRACT:

Background

The intricate relationship among gut microbiota, serum metabolites, and immunophenotypes may significantly impact myocarditis. However, direct causal links between these domains and myocarditis are not well understood.

Methods

The study performed Mendelian randomization (MR) analysis using genetic data from public sources. Exposure data included 211 gut microbiota, 486 serum metabolites, and 731 immunophenotypes from Mibiogen, the Metabolomics GWAS server, and GWAS catalog databases. Single nucleotide polymorphisms (SNPs) were selected as instrumental variables based on established criteria. Myocarditis data from GWAS (427,911 participants, 24, 180, 570 SNPs) were used as the outcome variable. MR analysis was conducted using Inverse Variance Weighting (IVW), with

SUBMITTER: Li K 

PROVIDER: S-EPMC11392795 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature