Luteolin exerts anti-tumour immunity in hepatocellular carcinoma by accelerating CD8⁺ T lymphocyte infiltration.

ABSTRACT: Luteolin, a commonly used traditional Chinese medicine, has been utilized for several decades in the treatment of hepatocellular carcinoma (HCC). Previous research has demonstrated its anti-tumour efficacy, but its underlying mechanism remains unclear. This study aimed to assess the therapeutic effects of luteolin in H22 tumour-bearing mice. luteolin effectively inhibited the growth of solid tumours in a well-established mouse model of HCC. High-throughput sequencing revealed that luteolin treatment could enhance T-cell activation, cell chemotaxis and cytokine production. In addition, luteolin helped sustain a high ratio of CD8⁺ T lymphocytes in the spleen, peripheral blood and tumour tissues. The effects of luteolin on the phenotypic and functional changes in tumour-infiltratin

SUBMITTER: Cai S 

PROVIDER: S-EPMC11392827 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature