Transcriptome-based identification of key actin-binding proteins associated with high metastatic potential in breast cancer.

ABSTRACT:

Introduction

Actin-binding proteins (ABPs) are essential for the regulation of morphological plasticity required for tumor cells to metastasize. The aim of this study was to perform an unbiased bioinformatic approach to identify the key ABPs significantly associated with the metastatic potential of breast cancer cells.

Methods

Microarray data from 181 primary breast cancer samples from our hospital were used, and all genes belonging to the Gene Ontology term actin cytoskeleton organization were obtained from QuickGO. Association with metastasis-free survival probability was tested using Cox proportional hazards regression, and pairwise co-expression was tested by Pearson correlations. Differential expression between different subgroups was analyzed using Wilcoxon tests for d

SUBMITTER: Muller C 

PROVIDER: S-EPMC11392851 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature