Potential causal link between dietary intake and epilepsy: a bidirectional and multivariable Mendelian randomization study.

ABSTRACT:

Background

Epilepsy is a common neurological disease, and dietary intake has been suggested as a potential modifiable risk factor. However, the causality of associations between dietary intake and epilepsy remains uncertain. This study aimed to investigate the potential causal relationships between various dietary intakes and epilepsy using Mendelian randomization (MR) analysis.

Methods

A two-sample MR approach was employed, utilizing genetic variants associated with dietary factors as instrumental variables (IVs). Genome-Wide Association Study (GWAS) summary data on dietary intakes were obtained from the UK Biobank, while data on epilepsy were sourced from the European Bioinformatics Institute. The number of genetic variants used as IVs varied for each dietary factor. Inver

SUBMITTER: Lai S 

PROVIDER: S-EPMC11392887 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature