Recent Advances and Methodological Considerations on Vaccine Candidates for Human Schistosomiasis.

ABSTRACT: Schistosomiasis remains a neglected tropical disease of major public health concern with high levels of morbidity in various parts of the world. Although considerable efforts in implementing mass drug administration programs utilizing praziquantel have been deployed, schistosomiasis is still not contained. A vaccine may therefore be an essential part of multifaceted prevention control efforts. In the 1990s, a joint United Nations committee promoting parasite vaccines shortlisted promising candidates including for schistosomiasis discussed below. After examining the complexity of immune responses in human hosts infected with schistosomes, we review and discuss the antigen design and preclinical and clinical development of the four leading vaccine candidates: Sm-TSP-2 in Phase 1b/2b, Sm14 in

SUBMITTER: Panzner U 

PROVIDER: S-EPMC11392908 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature