Microglial process convergence onto injured axonal swellings, a human postmortem brain tissue study.

ABSTRACT: Traumatic brain injury (TBI) affects millions globally, with a majority of TBI cases being classified as mild, in which diffuse pathologies prevail. Two of the pathological hallmarks of TBI are diffuse axonal injury (DAI) and microglial activation. While progress has been made investigating the breadth of TBI-induced axonal injury and microglial changes in rodents, the neuroinflammatory progression and interaction between microglia and injured axons in humans is less well understood. Our group previously investigated microglial process convergence (MPC), in which processes of non-phagocytic microglia directly contact injured proximal axonal swellings, in rats and micropigs acutely following TBI. These studies demonstrated that MPC occurred on injured axons in the micropig, but not in the r

SUBMITTER: Logan-Wesley AL 

PROVIDER: S-EPMC11392954 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature