Influenza induces lung lymphangiogenesis independent of YAP/TAZ activity in lymphatic endothelial cells.

ABSTRACT: The lymphatic system consists of a vessel network lined by specialized lymphatic endothelial cells (LECs) that are responsible for tissue fluid homeostasis and immune cell trafficking. The mechanisms for organ-specific LEC responses to environmental cues are not well understood. We found robust lymphangiogenesis during influenza A virus infection in the adult mouse lung. We show that the number of LECs increases twofold at 7 days post-influenza infection (dpi) and threefold at 21 dpi, and that lymphangiogenesis is preceded by lymphatic dilation. We also show that the expanded lymphatic network enhances fluid drainage to mediastinal lymph nodes. Using EdU labeling, we found that a significantly higher number of pulmonary LECs are proliferating at 7 dpi compared to LECs in homeostatic condit

SUBMITTER: Crossey E 

PROVIDER: S-EPMC11393066 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature