A pharmacovigilance study on clinical factors of active vitamin D₃ analog-related acute kidney injury using the Japanese Adverse Drug Event Report Database.

ABSTRACT: Acute kidney injury (AKI) due to vitamin D therapy for osteoporosis is encountered in clinical practice, but epidemiological studies are scarce. We aimed to determine the association between AKI and vitamin D therapy and to identify risk factors for AKI using the Japanese Adverse Drug Event Report database. We used reporting odds ratios (RORs) to detect signals and evaluate risk factors using multiple logistic regression analysis. Among 298,891 reports from April 2004 to September 2023, 1071 implicated active vitamin D₃ analogs as suspect drugs for adverse events. There was a significant association between AKI and active vitamin D₃ analogs (ROR [95% confidence interval {CI}], eldecalcitol: 16.75 [14.23-19.72], P < 0.001; alfacalcidol: 5.29 [4.07-6.87], P < 0.001; cal

SUBMITTER: Kawai Y 

PROVIDER: S-EPMC11393075 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature