Use of drugs for hypertension or heart failure and the risk of death in COVID-19: association with loop-diuretics.

ABSTRACT:

Purpose

To study the association between the use of drugs for hypertension or heart failure, particularly diuretics, and risk of death in COVID-19.

Methods

We conducted a cohort study, based on record linked individual-based data from national registers, of all Swedish inhabitants 50 years and older (n = 3,909,321) at the start of the first SARS-CoV-2 wave in Sweden. The association between use of angiotensin-converting enzyme inhibitors (ACEI), angiotensin II receptor blockers (ARB), thiazides, loop diuretics, aldosterone antagonists, beta blocking agents and calcium channel blockers at the index date 6 March 2020, and death in COVID-19 during 7 March to 31 July 2020, was analysed using Cox-proportional hazards regression, adjusted for a wide range of possible confounders.<

SUBMITTER: Fastbom J 

PROVIDER: S-EPMC11393138 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature