RAC1 serves as a prognostic factor and correlated with immune infiltration in liver hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (LIHC) has severe consequences due to late diagnosis and the lack of effective therapies. Currently, potential biomarkers for the diagnosis and prognosis of LIHC have not been systematically evaluated. Previous studies have reported that RAC1 is associated with the B cell receptor signaling pathway in various tumor microenvironments, but its relationship with LIHC remains unclear. We investigated the relationship between RAC1 and the prognosis and immune infiltration microenvironment of LIHC, exploring its potential as a prognostic biomarker for this type of cancer.

Methods

In this study, we analyzed data from The Cancer Genome Atlas (TCGA) using the Wilcoxon signed-rank test and logistic regression to assess the association between RAC1 e

SUBMITTER: Li Y 

PROVIDER: S-EPMC11393158 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature