Fibrates and risk of congenital malformations: a nationwide cohort study in South Korea.

ABSTRACT:

Purpose

To examine the association between maternal prescriptions for fibrates and congenital malformations in live births.

Methods

Nationwide retrospective cohort study was conducted using the data sourced from the Korean National Health Insurance database. A cohort of 756,877 completed pregnancies linked to live-born infants in 215,600 women with dyslipidemia between 2012 and 2021. The study compared data on congenital anomalies between pregnancies who were exposed to fibrates and those who were not exposed to fibrates in the first trimester. Odds ratios (OR) were calculated by a multivariable analyses using logistic regression models to adjust for potential confounders.

Results

260 pregnancies (0.12%) were exposed to fibrates during the first trimester. The prevale

SUBMITTER: Kay HY 

PROVIDER: S-EPMC11393199 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature