Circadian rhythms and breast cancer: from molecular level to therapeutic advancements.

ABSTRACT:

Background and objectives

Circadian rhythms, the endogenous biological clocks that govern physiological processes, have emerged as pivotal regulators in the development and progression of breast cancer. This comprehensive review delves into the intricate interplay between circadian disruption and breast tumorigenesis from multifaceted perspectives, encompassing biological rhythms, circadian gene regulation, tumor microenvironment dynamics, and genetic polymorphisms.

Methods and results

Epidemiological evidence underscores the profound impact of external factors, such as night shift work, jet lag, dietary patterns, and exercise routines, on breast cancer risk and progression through the perturbation of circadian homeostasis. The review elucidates the distinct roles of key cir

SUBMITTER: Li DD 

PROVIDER: S-EPMC11393214 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature