Folate intake and colorectal cancer risk according to genetic subtypes defined by targeted tumor sequencing.

ABSTRACT:

Background

Folate is involved in multiple genetic, epigenetic, and metabolic processes, and inadequate folate intake has been associated with an increased risk of cancer.

Objective

We examined whether folate intake is differentially associated with colorectal cancer (CRC) risk according to somatic mutations in genes linked to CRC using targeted sequencing.

Design

Participants within 2 large CRC consortia with available information on dietary folate, supplemental folic acid, and total folate intake were included. Colorectal tumor samples from cases were sequenced for the presence of nonsilent mutations in 105 genes and 6 signaling pathways (IGF2/PI3K, MMR, RTK/RAS, TGF-β, WNT, and TP53/ATM). Multinomial logistic regression models were analyzed comparing mutated/nonmuta

SUBMITTER: Aglago EK 

PROVIDER: S-EPMC11393398 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature