ROS-sensitive PD-L1 siRNA cationic selenide nanogels for self-inhibition of autophagy and prevention of immune escape.

ABSTRACT: In the field of cancer therapy, inhibiting autophagy has emerged as a promising strategy. However, pharmacological disruption of autophagy can lead to the upregulation of programmed death-ligand 1 (PD-L1), enabling tumor immune evasion. To address this issue, we developed innovative ROS-responsive cationic poly(ethylene imine) (PEI) nanogels using selenol chemistry-mediated multicomponent reaction (MCR) technology. This procedure involved simple mixing of low-molecular-weight PEI (LMW PEI), γ-selenobutylacetone (γ-SBL), and poly(ethylene glycol) methacrylate (PEGMA). Through high-throughput screening, we constructed a library of A_xSe_yO_z nanogels and identified the optimized A_1.8Se₃O_0.5/siPD-L1 nanogels, which exhibited a siz

SUBMITTER: Gao J 

PROVIDER: S-EPMC11393550 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature