Association between Helicobacter pylori antibodies and otolaryngological diseases.

ABSTRACT:

Objective

Observational studies have shown that Helicobacter pylori is related to some otolaryngological diseases. However, it is unclear if H. pylori infection causally affects these diseases. To elucidate H. pylori role in 12 common otolaryngological diseases, we conducted two-sample Mendelian randomization analysis.

Methods

Single-nucleotide polymorphisms associated with 7 H. pylori antibodies (IgG, CagA, Catalase, GroEL, OMP, UREA and Vac A) served as instrumental variables. We primarily employed random-effects inverse variance weighting for causal estimation, supplemented by MR Egger, weighted median, simple mode, and weighted mode. Sensitivity analyses, including heterogeneity, pleiotropy, and leave-one-out tests, validated robustness.

Results

MR analysis using

SUBMITTER: Zhang F 

PROVIDER: S-EPMC11393579 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature