Genetics of cell-type-specific post-transcriptional gene regulation during human neurogenesis.

ABSTRACT: The function of some genetic variants associated with brain-relevant traits has been explained through colocalization with expression quantitative trait loci (eQTL) conducted in bulk postmortem adult brain tissue. However, many brain-trait associated loci have unknown cellular or molecular function. These genetic variants may exert context-specific function on different molecular phenotypes including post-transcriptional changes. Here, we identified genetic regulation of RNA editing and alternative polyadenylation (APA) within a cell-type-specific population of human neural progenitors and neurons. More RNA editing and isoforms utilizing longer polyadenylation sequences were observed in neurons, likely due to higher expression of genes encoding the proteins mediating these post-transcripti

SUBMITTER: Aygun N 

PROVIDER: S-EPMC11393701 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature