Persistent Lymph Node Metastases After Neoadjuvant Chemoradiotherapy for Rectal Cancer.

ABSTRACT:

Importance

Patients with locally advanced rectal cancer and persistent lymph node metastases (PLNM) after neoadjuvant treatment are at high risk of developing locoregional and distant metastasis, yet optimal postsurgical treatment of these patients is limited.

Objective

To analyze the association of PLNM with pretreatment clinical parameters, intensity of neoadjuvant treatment, and long-term oncological outcomes.

Design, setting, and participants

This cohort study is a post-hoc analysis of 3 randomized clinical trials (Surgical Oncology Working Group of Germany [CAO], Radiological Oncology Working Group of Germany [ARO], and Working Group for Internal Oncology in the German Cancer Society [AIO]) conducted in Germany in 1994, 2004, and 2012 that included 1948 patients

SUBMITTER: Diefenhardt M 

PROVIDER: S-EPMC11393720 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature