Economic Evaluation of Population-Based BRCA1 and BRCA2 Testing in Canada.

ABSTRACT:

Importance

Population-based BRCA testing can identify many more BRCA carriers who will be missed by the current practice of BRCA testing based on family history (FH) and clinical criteria. These carriers can benefit from screening and prevention, potentially preventing many more breast and ovarian cancers and deaths than the current practice.

Objective

To estimate the incremental lifetime health outcomes, costs, and cost-effectiveness associated with population-based BRCA testing compared with FH-based testing in Canada.

Design, setting, and participants

For this economic evaluation, a Markov model was developed to compare the lifetime costs and outcomes of BRCA1/BRCA2 testing for all general population women aged 30 years compared with FH-based testing. BRCA carriers

SUBMITTER: Sun L 

PROVIDER: S-EPMC11393724 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature