Extending the Range of Detectable Trace Species with the Fast Polarity Switching of Chemical Ionization Orbitrap Mass Spectrometry.

ABSTRACT: Chemical ionization (CI) atmospheric pressure interface mass spectrometry is a unique analytical technique for its low detection limits, softness to preserve molecular information, and selectivity for particular classes of species. Here, we present a fast polarity switching approach for highly sensitive online analysis of a wide range of trace species in complex samples using selective CI chemistries and high-resolution mass spectrometry. It is achieved by successfully coupling a multischeme chemical ionization inlet (MION) and an Orbitrap Fourier transform mass spectrometer. The capability to flexibly combine ionization chemistries from both polarities effectively extends the detectability compared to using only one ionization chemistry, as commonly used positive and negative reagent ions

SUBMITTER: Cai R 

PROVIDER: S-EPMC11393793 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature